Isopropyl Acetate 99.98% ACS Grade

Product Identifier

Isopropyl Acetate 99.98% ACS Grade

Grade

ACS Grade

Concentration

99.98%

CAS Number

108-21-4

Molecular Weight

102.13 g/mol

IUPAC Name

propan-2-yl acetate

Manufacturer

Alliance Chemical
204 South Edmond Street, Taylor, TX 76574

Emergency Phone

Chemtel 1-800-255-3924 (24/7)

Synonyms

Isopropyl ethanoate; 1-methylethyl acetate; acetic acid isopropyl ester; IPAc

Recommended Use

Laboratory and analytical solvent (ACS grade): extraction, chromatography and synthesis.

Restrictions on Use

Not for food, drug or household use. Highly flammable: use with adequate ventilation, away from ignition sources.

Classification

• Flammable liquids, Category 2
• Serious eye damage/eye irritation, Category 2A
• Specific target organ toxicity, single exposure, Category 3 (narcotic effects)

Signal Word

Danger

Hazard Statements

• H225Highly flammable liquid and vapor
• H319Causes serious eye irritation
• H336May cause drowsiness or dizziness

Precautionary Statements

• P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P233Keep container tightly closed.
• P240Ground and bond container and receiving equipment.
• P241Use explosion-proof electrical, ventilating, and lighting equipment.
• P242Use non-sparking tools.
• P243Take precautionary measures against static discharge.
• P261Avoid breathing dust, fume, gas, mist, vapors or spray.
• P264Wash hands and face thoroughly after handling.
• P271Use only outdoors or in a well-ventilated area.
• P280Wear protective gloves, protective clothing, and eye/face protection.
• P303+P361+P353IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
• P304+P340IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312Call a POISON CENTER or doctor if you feel unwell.
• P337+P313If eye irritation persists: Get medical advice or attention.
• P370+P378In case of fire: Use alcohol-resistant foam, CO2 or dry chemical powder to extinguish.
• P403+P233Store in a well-ventilated place. Keep container tightly closed.
• P403+P235Store in a well-ventilated place. Keep cool.
• P405Store locked up.
• P501Dispose of contents and container in accordance with local, regional, national, and international regulations.

Classification, hazard (H) and precautionary (P) statements and pictograms per OSHA HCS 2024 (29 CFR 1910.1200, Appendices A–C), aligned with GHS Rev. 7.

Concentrations are nominal; lot-specific values appear on the Certificate of Analysis. Components not contributing to classification are omitted.

Eyes

Rinse with plenty of water for at least 15 minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention immediately.

Skin

Immediately flush with plenty of water for at least 15 minutes while removing contaminated clothing. Wash with soap. Get medical attention immediately.

Inhalation

Move person to fresh air and keep comfortable for breathing. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Get medical attention immediately.

Ingestion

Do Not Induce Vomiting! Never give anything by mouth to an unconscious person. If conscious, wash out mouth with water. Get medical attention immediately.

Most Important Symptoms and Effects

• Eye contact causes irritation: redness, pain and tearing.
• Inhalation of vapors may cause drowsiness, dizziness, headache and nausea.

Immediate Medical Attention and Special Treatment

• Treat symptomatically. Get medical attention if symptoms develop or persist.

Suitable Extinguishing Media

Alcohol-resistant foam, CO2, dry chemical powder. Water spray may be used to cool fire-exposed containers.

Unsuitable Extinguishing Media

Do not use a solid water stream — may scatter and spread fire.

Specific Hazards Arising from the Chemical

Vapors are heavier than air and may form explosive mixtures with air; they can travel to a source of ignition and flash back. Containers may rupture when heated.

Protective Equipment

Wear self-contained breathing apparatus and full protective clothing.

Hazardous Combustion Products

Carbon monoxide and carbon dioxide on combustion.

Personal Precautions

Use PPE as described in Section 8. Ensure adequate ventilation. Evacuate personnel to safe areas.

Hazard-Specific Precautions

Eliminate all ignition sources. Use non-sparking tools and explosion-proof equipment; ground and bond containers during cleanup.

Environmental Precautions

Prevent leakage or spillage from entering drains, sewers, or waterways.

Containment & Cleanup

Absorb with inert material. Collect in appropriate waste container. Dispose per applicable regulations.

Safe Handling

Use with adequate ventilation. Avoid contact with skin, eyes, and clothing. Wash thoroughly after handling. Keep container closed when not in use.

Safe Storage

Store in a cool, dry, well-ventilated area away from heat, sparks, and open flame. Keep away from incompatible materials (see Section 10). Keep containers tightly closed. Ground and bond containers when transferring material.

Specific Storage Precautions

Keep tightly closed in a cool, well-ventilated flammables area away from ignition sources, oxidizers, acids and bases. Store locked up. Ground and bond containers.

Occupational Exposure Limits

Engineering Controls

Use adequate ventilation. Provide eyewash stations and quick-drench showers accessible to areas of use.

Eye/Face Protection

Wear chemical safety goggles or face shield.

Skin Protection

Wear chemical-resistant gloves and protective clothing.

Respiratory Protection

Use a NIOSH-approved respirator with organic vapor cartridges. For confined spaces or exposures above the OEL, use supplied-air respiratory protection.

Exposure limits sourced from NIOSH Pocket Guide, OSHA 29 CFR 1910.1000 and ACGIH TLVs.

Appearance

Colorless, volatile liquid

Odor

Sweet, fruity ester odor

Odor Threshold

No data available

pH

No data available

Melting Point / Freezing Point

-73 °C (-100 °F)

Boiling Point

89 °C (192 °F)

Flash Point

2–5 °C (36–41 °F), closed cup

Evaporation Rate

No data available

Flammability (solid, gas)

No data available

Upper/Lower Flammability or Explosive Limits

LEL 1.8% / UEL 8% (v/v in air)

Vapor Pressure

About 48 mmHg (6.5 kPa) at 20–21 °C

Vapor Density

3.5 (air = 1)

Relative Density

0.872 at 20 °C (water = 1)

Solubility

Slightly soluble in water (about 31 g/L at 20 °C); miscible with most organic solvents

Partition Coefficient (n-octanol/water)

No data available

Auto-ignition Temperature

479 °C (894 °F)

Decomposition Temperature

No data available

Viscosity

About 0.5 mPa·s at 25 °C

Particle Characteristics

Not applicable

Form

Liquid

Density

0.874 at 68 °F (USCG, 1999) - Less dense than water; will float

Refractive Index

1.376 - 1.378

Values shown reflect product-specific canonical data. Lot-specific ranges may vary; see the Certificate of Analysis for the shipped lot.

Reactivity

Not reactive under normal conditions of use and storage.

Chemical Stability

Stable under recommended storage conditions.

Possibility of Hazardous Reactions

None under normal processing conditions.

Conditions to Avoid

Heat, sparks, open flame, static discharge and other ignition sources.

Incompatible Materials

Strong oxidizing agents; strong acids and bases (hydrolysis).

Hazardous Decomposition Products

Carbon monoxide and carbon dioxide on combustion.

See below for route-specific acute toxicity data.

Likely Routes of Exposure

Inhalation, skin contact, eye contact, ingestion.

Symptoms

• Eye contact causes irritation: redness, pain and tearing.
• Inhalation of vapors may cause drowsiness, dizziness, headache and nausea.

Delayed and Chronic Effects

• No delayed or chronic effects identified beyond the classification in Section 2.

Carcinogen Classification

Ecotoxicity

Data not available. Avoid release to the environment.

Persistence & Degradability

Hydrolyzes slowly (half-life 2.4 yr at pH 7); air half-life ~4.6 d — Biodegrades (61% in 5 d / 76% in 20 d, domestic wastewater inoculum)

Bioaccumulative Potential

BCF 2 (estimated; low)

Mobility in Soil

Very high soil mobility (estimated Koc 15)

Dispose of contents/container in accordance with applicable federal, state, and local regulations. Do not dispose of into drains or waterways.

EPA RCRA Waste Codes

D001 (ignitable). Isopropyl acetate is not a P-, U- or F-listed waste.

If discarded, this material may be an ignitable hazardous waste (EPA RCRA D001, 40 CFR 261.21(a)(1): flash point below 60 °C; aqueous solutions with less than 24% alcohol by volume are excluded). The waste generator must make the final hazardous-waste determination.

US DOT (49 CFR)

UN Number

UN1220

Proper Shipping Name

Isopropyl acetate

Hazard Class

3

Packing Group

II

Additional US DOT Requirements

Inner packagings of 1 L or less may ship as Limited Quantity (49 CFR 173.150(b)). Not a marine pollutant.

IMDG / IATA classifications may differ from US DOT. Verify current regulations before international shipment.

CERCLA Reportable Quantity (RQ)

Not a CERCLA hazardous substance (no RQ); not an EPCRA Section 313 chemical.

SARA 311/312 hazard categories correspond to the GHS classification in Section 2. Data retrieved as of: California Proposition 65 2026-10-02; US EPA TSCA Active Inventory 2026-10-02; EPCRA SARA 313 (TRI) 2026-10-02.

Revision Date

2026-10-08

Format

16-section format per OSHA HCS 2024 (29 CFR 1910.1200, Appendix D), aligned with GHS Rev. 7.