Industrial chemicals · Taylor, TXTechnical Data Sheet
Propylene Glycol USP Grade
USP Grade
- CAS number
- 57-55-6
- Structure
Structure · PubChem - Grade
- USP Grade
Identity & Composition
- Product Name
- Propylene Glycol USP Grade
- Alliance Code
- propylene-glycol-usp-grade
- Grade
- USP Grade
- Concentration
- —
- CAS Number
- 57-55-6PubChem
- Formula
- C3H8O2PubChem
- Molecular Weight
- 76.09PubChem
- Product Type
- Pure substance
Specifications
| Test | Specification | Typical | Method | Source |
|---|---|---|---|---|
| Assay (C3H8O2) | not less than 99.5 percent | 99.87 % | GC, thermal conductivity detector, 1-m x 4-mm column packed with 5% G16 on support S5, area normalization excluding air and water | Interpreted |
| Acidity | not more than 0.20 mL of 0.10 N sodium hydroxide is required | 0.06 | Titration of 10 mL with 0.10 N sodium hydroxide to phenolphthalein endpoint | Interpreted |
| Chloride | 0.007% | 0.000036 % | USP <221> | Interpreted |
| Heavy metals | 5 ppm | 0.64 ppm | Heavy metals (as Pb), sulfide colour comparison against lead standard | Interpreted |
| Identification A (Infrared Absorption) | Infrared Absorption 〈197F〉 on undried specimen | Passes test | USP <197F> | Interpreted |
| Iron | 0.50 weight ppm (maximum) | 0.060 ppm | — | Interpreted |
| Limit of Diethylene Glycol | NMT 0.10% | 0.0027% | GC, flame ionization detector, 0.53-mm x 30-m fused-silica G43 column, 2,2,2-trichloroethanol internal standard | Interpreted |
| Limit of Ethylene Glycol | NMT 0.10% | 0.00045% | GC, flame ionization detector, 0.53-mm x 30-m fused-silica G43 column, 2,2,2-trichloroethanol internal standard | Interpreted |
| Odor | Pass | Passes test | Sensory (odor) evaluation | Interpreted |
| Residual solvents | Pass | Passes test | USP <467> | Interpreted |
| Residue on ignition | 0.0070 wt% max (3.5 mg from 50 g) | 0.00045 wt% | Ignition of 50 g, residue moistened with 0.5 mL sulfuric acid and ignited to constant weight | Interpreted |
| Sulfate | 0.006% | 0.00040 % | USP <221> | Interpreted |
| Suspended matter | Pass | Passes test | — | Interpreted |
| Water | not more than 0.2% | 0.044 % | USP <921> Method I (Karl Fischer) | Interpreted |
| Elemental impurities | Meets USP <232> / ICH Q3D oral limits | Passes test | USP <232> / <233>, ICP-MS | Interpreted |
| arsenic | 1 ppm max | 0.026 ppm | — | Interpreted |
| distillation dp | 189 deg C max | 188.0 °C | — | Interpreted |
| distillation ibp | 185 deg C min | 186.7 °C | — | Interpreted |
| dpg | 0.1 %m/m max | 0.036 %m/m | — | Interpreted |
| pb | 1 mg/kg max | 0.014 mg/kg | — | Interpreted |
| meg | 0.001 %m/m max | 0.00044 %m/m | — | Interpreted |
| oxidizing substances | 0.2 ml max | 0.03 | — | Interpreted |
| po | 0.001 %m/m max | 0.00030 %m/m | — | Interpreted |
| tpg | 0.03 %m/m max | 0.0056 %m/m | — | Interpreted |
Values are reproduced from the current product reference. Source labels do not by themselves establish a supplier guarantee or a test result for your lot. Confirm applicable acceptance limits and request lot-specific documentation.
Available GradesSame CAS, alternate grades and concentrations
| Grade | Concentration | Typical Assay | SKU | TDS |
|---|---|---|---|---|
| This grade USP Grade | — | — | current | current |
| — | 60% | — | propylene-glycol-60-inhibited | View TDS → |
| Technical | 60% | — | propylene-glycol-60-technical-grade | View TDS → |
| USP | 60% | — | propylene-glycol-60-usp-grade | View TDS → |
| USP Grade | 50% | — | 50-propylene-glycol-usp-grade | View TDS → |
| Technical Grade | 40% | — | 40-propylene-glycol-technical-grade | View TDS → |
| USP Grade | 40% | — | 40-propylene-glycol-usp-grade | View TDS → |
| — | 20% | — | propylene-glycol-20-inhibited | View TDS → |
| Technical | 20% | — | propylene-glycol-20-technical-grade | View TDS → |
| USP | 20% | — | propylene-glycol-20-usp-grade | View TDS → |
| Technical Grade | — | — | propylene-glycol-technical-grade | View TDS → |
Typical assay shown is the rolling-window mean from the sibling product's most recent lots. Grade selection drives downstream end-use — verify the sibling grade matches your specification before substitution.
Physical & Chemical Properties
| Property | Value | Source |
|---|---|---|
| Appearance | Transparent, mobile, colorless glycol liquid | Adjudicated |
| Form | Liquid | Published reference |
| Color | 10 APHA (maximum) | Interpreted |
| Odor | Odorless to mild | Adjudicated |
| Specific Gravity | 1.036–1.040 at 20 °C (water = 1) | Adjudicated |
| Density | 1.04 at 68 °F (USCG, 1999) - Denser than water; will sink | Published reference |
| Boiling Point | 184–188 °C (363–370 °F) | Adjudicated |
| Melting Point | About -60 °C (-76 °F); supercools to a glass rather than crystallizing | Adjudicated |
| Flash Point | 103–107 °C (217–225 °F), closed cup | Adjudicated |
| Vapor Pressure | About 0.1–0.2 mmHg (20–30 Pa) at 25 °C | Adjudicated |
| Solubility (water) | Completely miscible with water | Adjudicated |
| Refractive Index (nD 20) | 1.4310 - 1.4330 | Interpreted |
| Viscosity | 43–49 mPa·s at 25 °C | Adjudicated |
Regulatory & Transport
DOT / 49 CFR
- UN Number
- Not regulatedAdjudicated
- Hazard Class
- Not regulatedAdjudicated
- Packing Group
- Not regulatedAdjudicated
- Proper Shipping Name
- Not regulatedAdjudicated
GHS / OSHA HCS 2024
- Signal Word
- Not regulatedAdjudicated
- H-Codes (Hazard Statements)
- Not applicableECHA C&L Inventory
- P-Codes (Precautionary Statements)
- Not applicableECHA C&L Inventory
Occupational Exposure Limits
- OSHA PEL (29 CFR 1910.1000)
- —no canonical
- ACGIH TLV
- 10 mg/m³ TWA (aerosol)Adjudicated
- NIOSH REL
- —no canonical
- NIOSH IDLH
- —no canonical
Transport descriptions reflect 49 CFR 172.101 lookup at time of publication. Sourced data: NIOSH Pocket Guide for REL/IDLH, OSHA Z-Tables for PEL. Always verify against the latest regulatory text before shipment-critical decisions.
Health & Fire Hazard
Acute Toxicology
- LD₅₀ Oral (rat)
- > 20,000 mg/kg (rat)Adjudicated
- LD₅₀ Dermal (rabbit)
- 20,800 mg/kgAdjudicated
Acute toxicology values from SDS Section 11 or NIOSH RTECS.
Supplier Qualification Packet
One zipped download containing the TDS, SDS, latest lot COA (when available), and a fresh Letter of Continuing Guaranty for Propylene Glycol USP Grade. Every file included is SHA-256 hashed and listed in a manifest your QA team can audit.
Applications
USP grade: humectant, solvent and carrier in pharmaceutical, food, cosmetic and personal-care formulations; low-toxicity heat-transfer fluid.Adjudicated
Restrictions on Use: USP grade: for use in drug, food and cosmetic products at levels permitted by the applicable regulations (21 CFR 184.1666).
Storage & Handling
- Recommended Storage
- Keep tightly closed (hygroscopic) in a cool, dry place away from oxidizers. Stainless steel, carbon steel, polyethylene or polypropylene containers.Adjudicated
- Handling Precautions
- Chemical-resistant gloves and splash goggles. Avoid contact with hot surfaces and hot process equipment. Inhibitor packages deplete in service — monitor rather than top up blindly.Class-level guidance — not product-specific; the SDS controls.
- Incompatibilities
- Strong oxidizing agents; strong acids; strong bases.Adjudicated
- Shelf Life
- Consult Technical Services for product-specific shelf life
For full hazard, PPE, and emergency response guidance, refer to the Safety Data Sheet (SDS) for this product. The SDS controls in all cases where guidance differs.
Packaging & Logistics
Shipping Description (US DOT)
Not regulated for transport.
Confirm against shipping documents and carrier requirements before tender.
Revision History
Last reviewed 2026-06-17 by Andre Taki, Chief Commercial Officer, DOT Hazmat–certified (49 CFR 172.704).
| Version | Date | Change | Trigger |
|---|---|---|---|
| 1.3 | 2026-10-07 | Canonical data updated: 19 fields changed via the provenance/adjudication pipeline.
| canonical_change |
| 1.2 | 2026-09-30 | Canonical data updated: 4 fields changed via the provenance/adjudication pipeline.
| canonical_change |
| 1.1 | 2026-06-17 | Canonical data re-verified: 3 fields updated against independent vendor SDSs, CLP Annex VI, 49 CFR, and OSHA HazCom 2024 (GHS classification, hazard/precautionary codes, signal word, physical properties as applicable).
| canonical_change |
| 1.0 | 2026-05-20 | Initial URL-first TDS published from canonical chemistry registry. | initial |
This Technical Data Sheet is provided for technical reference. The Safety Data Sheet (SDS) controls in all cases where guidance differs. Values reflect Alliance Chemical canonical data at time of generation; subsequent revisions are recorded in the Revision History above.